http://www.mpnlab.org/lab-photos-gallery daily 0.75 2014-05-07 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484868904-AMM9C5V32ICIJO7I6WUG/meded_rainbow.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484868904-AMM9C5V32ICIJO7I6WUG/meded_rainbow.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484836255-6G44JIEIR1S7QWE428C8/DSC_0005.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484845644-V66UNIWCDWVXH06ISLCO/DSC_0007.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484855409-9YGHGXD53I7VNK8P9JC3/DSC_0008.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484923824-CDLBF0HVZP569BTDXEPL/2014-05-05+10.12.05.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399485581261-XP0071WXHED84YX708D3/2014-05-05+09.41.11.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399485594285-ZFPRETRF5FEUKCWH8DBU/2014-05-05+10.04.56.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399485608002-HRKFF0Q2JQWI5C34ZMG9/DSC_0028-1.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484861811-C226GV4GVD58AS80D5MG/Sprague+Entry+Plaza.jpg Lab photos gallery http://www.mpnlab.org/t-cells-in-mpn daily 0.75 2014-05-07 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399439742614-4DIA2BW17I2BBKDPS57O/Presentation2-1.jpg T cells in MPN Overactive T cells target may normal hematopoietic stem cells, but not Jak2-mutant stem cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399439742614-4DIA2BW17I2BBKDPS57O/Presentation2-1.jpg T cells in MPN Overactive T cells target may normal hematopoietic stem cells, but not Jak2-mutant stem cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399439757213-BSTHXD1J10PFWS78K0FL/Presentation2-2.jpg T cells in MPN Overzealous pruning of normal HSCs allows the Jak2 mutants to proliferate. http://www.mpnlab.org/mpn-tree daily 0.75 2014-05-02 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182193-5G3PP0GGJDJIQIG5AE8N/hematopoietic+tree_normal.jpg Hematopoiesis and MPN - Normal Hematopoiesis The hematopoietic stem cell (HSC) gives rise to all other blood cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182193-5G3PP0GGJDJIQIG5AE8N/hematopoietic+tree_normal.jpg Hematopoiesis and MPN - Normal Hematopoiesis The hematopoietic stem cell (HSC) gives rise to all other blood cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182638-I0DJ3JPHX5CGDPC6D4JP/hematopoietic+tree_PV.jpg Hematopoiesis and MPN - Polycythemia Vera The JAK2V617F mutation arises in progenitor cells to initiate overexpansion of erythrocytes. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983181493-PVX3P2NA1M96LOFT1HRE/hematopoietic+tree_ET.jpg Hematopoiesis and MPN - Essential Thrombocythemia The Jak2V617F mutation in megakaryocytes results in excessive platelet production. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983181737-8Q9ITVDNPDFARG36XR6L/hematopoietic+tree_MF.jpg Hematopoiesis and MPN - Myelofibrosis The bone marrow becomes increasingly fibrotic, resulting in reduced blood cell production and, eventually, bone marrow failure. http://www.mpnlab.org/lab-photoshoot daily 0.75 2018-06-14 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745415601-BMGKXXJU4SG4VDAWHV4D/image-asset.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745415601-BMGKXXJU4SG4VDAWHV4D/image-asset.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745460109-VONNHFTHTKIK8EPW1JUA/Screen+Shot+2016-02-17+at+1.38.56+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745533375-QUKDKTFJUY60WGQWM11F/Screen+Shot+2016-02-17+at+1.38.10+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745541501-8IPLCA7GSX9MYCMVK8VB/Screen+Shot+2016-02-17+at+1.36.45+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745548175-YBUKWL5RMK2N92FNJ8M8/Screen+Shot+2016-02-17+at+1.36.23+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745563199-V7H8TWIFZ1BAM3ZAXD7K/Screen+Shot+2016-02-17+at+1.32.56+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1529005915996-ULI29F2DJPL67JMH4V9B/Screen+Shot+2016-02-17+at+1.10.54+PM.png Lab photoshoot http://www.mpnlab.org/participate daily 0.75 2018-08-18 http://www.mpnlab.org/join daily 0.75 2025-09-10 http://www.mpnlab.org/contact daily 0.75 2025-11-08 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399048729358-NFTA6H9U37I33I0G3T2N/sprague+hall.jpg Contact Us Sprague Hall http://www.mpnlab.org/protocols daily 0.75 2017-08-24 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399334792394-Q0XKHAJS3C9SXXTR2CGL/DSC_0011-2.JPG Protocols http://www.mpnlab.org/publications daily 0.75 2026-09-16 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399504191621-T63Q08SZY8WQMPJOU6SY/dark+overlay+1.jpg Publications https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1593209137423-XHTIDF6N5RFAYRAPVTEW/Visual_Abstract_NAC_Thrombosis.jpg Publications Craver BM, Ramanathan G, Hoang S, Chang X, Mendez Luque LF, Brooks S, Lai HY, Fleischman AG; N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm. Blood Adv 2020; 4 (2): 312–321. http://www.mpnlab.org/mutated-calreticulin-in-mpn daily 0.75 2014-05-07 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399494284048-NZQDFXRJ64QUP0PF5OPW/macrophages+%2Bgranulocytes%2BCFSE+overlay.jpg Role of mutated calreticulin in MPN http://www.mpnlab.org/research-projects daily 0.75 2026-09-16 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399324762858-3S5ROJI7W2FRD03CFYJY/methylcellulose.jpg Overview of our research http://www.mpnlab.org/inflammation daily 0.75 2014-05-06 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399334890421-HO4KYNWYDJXA6W75N2P4/cropped-banner-version-3.jpg Excessive Inflammation in MPN https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399339329756-C19DT26TDZYFGOAWZ26B/image-asset.png Excessive Inflammation in MPN Signalling cascades following TLR ligation http://www.mpnlab.org/home daily 1.0 2025-11-08 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/17c68305-3e04-4f84-9f12-58a9417f4fe3/Resized_20251031_103440%280%29+2.jpg Welcome to the Fleischman Lab! https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399071083143-A4MAONNFJL4FVNOK8EO8/research+projects.jpg Welcome to the Fleischman Lab! https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1422926572246-IQF2CIIEF37ENM8PLAZX/image-asset.jpeg Welcome to the Fleischman Lab! https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399070179068-YDPA5B2NHVIDUE1WIFAP/visit-thumb.jpg Welcome to the Fleischman Lab! http://www.mpnlab.org/patient-resources daily 0.75 2016-02-03 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399488678880-2NID7EBXCMXH66TQ5HRR/Myelofibrosis%2C_Reticulin_Stain_%286032644716%29.jpg Patient Resources http://www.mpnlab.org/lab-alumni daily 0.75 2025-09-10 http://www.mpnlab.org/fleischman daily 0.75 2023-02-15 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1593209882232-X7S2JYEEQGD05NF8KBR9/Angela_2019.jpg PI: Angela Fleischman, MD, PhD http://www.mpnlab.org/we-are-mpn daily 0.75 2015-10-15 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1437715186870-AKWXP9N25X5NBMY5WORO/we+are+mpn+banner.jpg We Are MPN https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1444865196675-NJNIFUHTV68OHSA83V90/FINAL+2015+Agenda+Insert.jpg We Are MPN http://www.mpnlab.org/participate-in-studies daily 0.75 2020-06-26 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1534599619661-C33PDIGU3PLZ13V456EM/Could-Helping-Others-Be-the-Key-to-Healing.jpg Participate in MPN Research Studies http://www.mpnlab.org/eli-soyfer daily 0.75 2026-08-22 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/f18efff2-3de9-449e-af8a-2a0821db3cbb/Eli+Soyfer+-+Headshot.jpg Eli Soyfer, PhD http://www.mpnlab.org/undergraduates daily 0.75 2026-09-21 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/33d2cf75-d767-4c9b-b55b-70ab53345998/IMG_0120.jpg Undergraduates AALIYAH OKOJI Aaliyah is a fourth-year Human Biology major with an interest in pursuing a career in the medical field. She joined the Fleischman Lab in the spring of 2024 to gain hands-on research experience and learn more about blood disorders and cancer biology. Since joining the lab, she has developed a strong interest in myeloproliferative neoplasms and the biological mechanisms underlying these diseases. She is excited to continue expanding her research skills, deepening her understanding of hematology and oncology, and contributing to research that may help improve patient care. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1f5b4161-2149-4130-9549-ac469fda21bd/image.jpg Undergraduates SAFIA FATIMA AHMED Safia is a fourth-year Biological Sciences major hoping to pursue a career as a RDN in the future. She joined the lab in Fall 2025 and is primarily interested in studying the influence of diet on CHIP associated mutations. Safia is excited to learn new experimental techniques in the lab to strengthen her understanding of cell biology and hematology. http://www.mpnlab.org/lucas-wadley daily 0.75 2026-08-22 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/f2f618bf-8406-4624-a572-4c26c30654e4/10.17.25+STEMM+Research+Poster+Symposium+0077.JPG Lucas Wadley Lucas Wadley giving a talk as a guest speaker at Nevada State University. 10.17.2025 http://www.mpnlab.org/kaleiguillermo-ms daily 0.75 2026-09-18 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/19e10b2f-5908-45d1-806d-752fe61e30c3/08294.png Kalei Guillermo, MS http://www.mpnlab.org/camille-brzechffa daily 0.75 2025-09-11 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/61a81261-2e73-431f-8fbd-0e1442e1111e/CB-photo.jpg Camille Brzechffa http://www.mpnlab.org/contact-us daily 0.75 2026-09-17 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399048729358-NFTA6H9U37I33I0G3T2N/sprague+hall.jpg Contact Us Sprague Hall http://www.mpnlab.org/join-the-lab daily 0.75 2026-09-17 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399333171209-PVOMYI5NVOKMU08J1DA0/lab+bench1.jpg Join the Lab http://www.mpnlab.org/clonal-competition daily 0.75 2026-09-16 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/abb5f48b-027b-498f-b255-a4a7d5d216a0/ChatGPT+Image+Sep+16%2C+2026%2C+04_12_45+PM.png clonal competition - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://www.mpnlab.org/chip-and-diet daily 0.75 2026-09-16 http://www.mpnlab.org/hsc-aging daily 0.75 2026-09-16 http://www.mpnlab.org/interferon-sensitivity daily 0.75 2026-09-16 http://www.mpnlab.org/famililal-mpn-studies daily 0.75 2026-09-16 http://www.mpnlab.org/lab-events daily 0.75 2026-09-21 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/739fc550-b2f0-44d1-b184-2759185037d8/ED4120BB-AA01-4CF4-9EA6-4B70C2BE58F7_1_105_c.jpeg Lab Events - Make it stand out Whatever it is, the way you tell your story online can make all the difference.