http://www.mpnlab.org/lab-photos-gallery daily 0.75 2014-05-07 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484868904-AMM9C5V32ICIJO7I6WUG/meded_rainbow.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484868904-AMM9C5V32ICIJO7I6WUG/meded_rainbow.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484836255-6G44JIEIR1S7QWE428C8/DSC_0005.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484845644-V66UNIWCDWVXH06ISLCO/DSC_0007.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484855409-9YGHGXD53I7VNK8P9JC3/DSC_0008.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484923824-CDLBF0HVZP569BTDXEPL/2014-05-05+10.12.05.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399485581261-XP0071WXHED84YX708D3/2014-05-05+09.41.11.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399485594285-ZFPRETRF5FEUKCWH8DBU/2014-05-05+10.04.56.jpg Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399485608002-HRKFF0Q2JQWI5C34ZMG9/DSC_0028-1.JPG Lab photos gallery https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399484861811-C226GV4GVD58AS80D5MG/Sprague+Entry+Plaza.jpg Lab photos gallery http://www.mpnlab.org/t-cells-in-mpn daily 0.75 2014-05-07 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399439742614-4DIA2BW17I2BBKDPS57O/Presentation2-1.jpg T cells in MPN Overactive T cells target may normal hematopoietic stem cells, but not Jak2-mutant stem cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399439742614-4DIA2BW17I2BBKDPS57O/Presentation2-1.jpg T cells in MPN Overactive T cells target may normal hematopoietic stem cells, but not Jak2-mutant stem cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399439757213-BSTHXD1J10PFWS78K0FL/Presentation2-2.jpg T cells in MPN Overzealous pruning of normal HSCs allows the Jak2 mutants to proliferate. http://www.mpnlab.org/mpn-tree daily 0.75 2014-05-02 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182193-5G3PP0GGJDJIQIG5AE8N/hematopoietic+tree_normal.jpg Hematopoiesis and MPN - Normal Hematopoiesis The hematopoietic stem cell (HSC) gives rise to all other blood cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182193-5G3PP0GGJDJIQIG5AE8N/hematopoietic+tree_normal.jpg Hematopoiesis and MPN - Normal Hematopoiesis The hematopoietic stem cell (HSC) gives rise to all other blood cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182638-I0DJ3JPHX5CGDPC6D4JP/hematopoietic+tree_PV.jpg Hematopoiesis and MPN - Polycythemia Vera The JAK2V617F mutation arises in progenitor cells to initiate overexpansion of erythrocytes. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983181493-PVX3P2NA1M96LOFT1HRE/hematopoietic+tree_ET.jpg Hematopoiesis and MPN - Essential Thrombocythemia The Jak2V617F mutation in megakaryocytes results in excessive platelet production. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983181737-8Q9ITVDNPDFARG36XR6L/hematopoietic+tree_MF.jpg Hematopoiesis and MPN - Myelofibrosis The bone marrow becomes increasingly fibrotic, resulting in reduced blood cell production and, eventually, bone marrow failure. http://www.mpnlab.org/lab-photoshoot daily 0.75 2018-06-14 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745415601-BMGKXXJU4SG4VDAWHV4D/image-asset.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745415601-BMGKXXJU4SG4VDAWHV4D/image-asset.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745460109-VONNHFTHTKIK8EPW1JUA/Screen+Shot+2016-02-17+at+1.38.56+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745533375-QUKDKTFJUY60WGQWM11F/Screen+Shot+2016-02-17+at+1.38.10+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745541501-8IPLCA7GSX9MYCMVK8VB/Screen+Shot+2016-02-17+at+1.36.45+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745548175-YBUKWL5RMK2N92FNJ8M8/Screen+Shot+2016-02-17+at+1.36.23+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455745563199-V7H8TWIFZ1BAM3ZAXD7K/Screen+Shot+2016-02-17+at+1.32.56+PM.png Lab photoshoot https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1529005915996-ULI29F2DJPL67JMH4V9B/Screen+Shot+2016-02-17+at+1.10.54+PM.png Lab photoshoot http://www.mpnlab.org/lymphocytes-in-mpn daily 0.75 2014-07-31 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399504018627-AHHCQ0XQTV00UMZZD839/flow+banner.png Role of Lymphocytes in MPN Pathogenesis http://www.mpnlab.org/participate daily 0.75 2018-08-18 http://www.mpnlab.org/join daily 0.75 2025-09-10 http://www.mpnlab.org/contact daily 0.75 2025-11-08 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399048729358-NFTA6H9U37I33I0G3T2N/sprague+hall.jpg Contact Us Sprague Hall http://www.mpnlab.org/protocols daily 0.75 2017-08-24 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399334792394-Q0XKHAJS3C9SXXTR2CGL/DSC_0011-2.JPG Protocols http://www.mpnlab.org/publications daily 0.75 2025-09-10 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1593209137423-XHTIDF6N5RFAYRAPVTEW/Visual_Abstract_NAC_Thrombosis.jpg Publications Craver BM, Ramanathan G, Hoang S, Chang X, Mendez Luque LF, Brooks S, Lai HY, Fleischman AG; N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm. Blood Adv 2020; 4 (2): 312–321. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399504191621-T63Q08SZY8WQMPJOU6SY/dark+overlay+1.jpg Publications http://www.mpnlab.org/mutated-calreticulin-in-mpn daily 0.75 2014-05-07 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399494284048-NZQDFXRJ64QUP0PF5OPW/macrophages+%2Bgranulocytes%2BCFSE+overlay.jpg Role of mutated calreticulin in MPN http://www.mpnlab.org/research-projects daily 0.75 2014-07-31 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182193-5G3PP0GGJDJIQIG5AE8N/hematopoietic+tree_normal.jpg Overview of our research - Normal Hematopoiesis The hematopoietic stem cell (HSC) gives rise to all other blood cells. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983182638-I0DJ3JPHX5CGDPC6D4JP/hematopoietic+tree_PV.jpg Overview of our research - Polycythemia Vera The JAK2V617F mutation arises in progenitor cells to initiate overexpansion of erythrocytes. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983181493-PVX3P2NA1M96LOFT1HRE/hematopoietic+tree_ET.jpg Overview of our research - Essential Thrombocythemia The Jak2V617F mutation in megakaryocytes results in excessive platelet production. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1398983181737-8Q9ITVDNPDFARG36XR6L/hematopoietic+tree_MF.jpg Overview of our research - Myelofibrosis The bone marrow becomes increasingly fibrotic, resulting in reduced blood cell production and, eventually, bone marrow failure. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399324762858-3S5ROJI7W2FRD03CFYJY/methylcellulose.jpg Overview of our research http://www.mpnlab.org/inflammation daily 0.75 2014-05-06 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399339329756-C19DT26TDZYFGOAWZ26B/image-asset.png Excessive Inflammation in MPN Signalling cascades following TLR ligation https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399334890421-HO4KYNWYDJXA6W75N2P4/cropped-banner-version-3.jpg Excessive Inflammation in MPN http://www.mpnlab.org/home daily 1.0 2025-11-08 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399070179068-YDPA5B2NHVIDUE1WIFAP/visit-thumb.jpg Welcome to the Fleischman Lab! https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399071083143-A4MAONNFJL4FVNOK8EO8/research+projects.jpg Welcome to the Fleischman Lab! https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1422926572246-IQF2CIIEF37ENM8PLAZX/image-asset.jpeg Welcome to the Fleischman Lab! https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/17c68305-3e04-4f84-9f12-58a9417f4fe3/Resized_20251031_103440%280%29+2.jpg Welcome to the Fleischman Lab! http://www.mpnlab.org/patient-resources daily 0.75 2016-02-03 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399488678880-2NID7EBXCMXH66TQ5HRR/Myelofibrosis%2C_Reticulin_Stain_%286032644716%29.jpg Patient Resources http://www.mpnlab.org/lab-alumni daily 0.75 2025-09-10 http://www.mpnlab.org/fleischman daily 0.75 2023-02-15 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1593209882232-X7S2JYEEQGD05NF8KBR9/Angela_2019.jpg PI: Angela Fleischman, MD, PhD http://www.mpnlab.org/we-are-mpn daily 0.75 2015-10-15 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1444865196675-NJNIFUHTV68OHSA83V90/FINAL+2015+Agenda+Insert.jpg We Are MPN https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1437715186870-AKWXP9N25X5NBMY5WORO/we+are+mpn+banner.jpg We Are MPN http://www.mpnlab.org/heme-biorepository daily 0.75 2019-06-19 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455220565955-ICFCRPS0MSCDMYMFW7PC/image-asset.png Heme Biorepository https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1554685323476-25VXLCCA84JUHNC4B1T7/QR%2Bcode%2Bconsent%2Bppt.jpg Heme Biorepository https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1455744193384-KV2RPXYM5CZQRS3EYCCX/biorepositor+logo1.jpg Heme Biorepository http://www.mpnlab.org/participate-in-studies daily 0.75 2020-06-26 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1534599619661-C33PDIGU3PLZ13V456EM/Could-Helping-Others-Be-the-Key-to-Healing.jpg Participate in MPN Research Studies http://www.mpnlab.org/heme-biorepository-info-for-patients daily 0.75 2019-06-19 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1560963987606-YYMWUQTDKHCWGXJS1DFS/qr+code+for+biobank.png Heme biorepository info for patients QR code for online consent http://www.mpnlab.org/eli-soyfer-phd daily 0.75 2025-09-11 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/f18efff2-3de9-449e-af8a-2a0821db3cbb/Eli+Soyfer+-+Headshot.jpg Eli Soyfer, PhD http://www.mpnlab.org/gaja-ramanathan-phd-copy daily 0.75 2024-11-21 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/5acca10e-c85a-4750-ad5b-824c1663367b/IMG_3328+3.JPG Jeanette Sullivan http://www.mpnlab.org/new-page-1 daily 0.75 2024-11-21 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/28a3c646-1888-42bc-b479-0a4c13ef222d/IMG_6146.JPG Technicians HELEN HUANG Helen was born in Shenzhen, China and finished her high school in Maryland. She graduated in March 2023. Helen assisted Gaja with DNA isolation from mouse blood and human samples, PCR and gel electrophoresis, mouse bone marrow isolation, cell culture of primary cells and established cell lines, flow cytometry for phosphoflow and staining and analyzing mouse blood samples by flow cytometry. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/97784af5-9b88-4e03-a1d2-e397f44168e1/23uci-54697521-14-1008594849-1.jpg Technicians JIANHONG HEIDMANN Jianhong joined the lab during the summer of 2022. She majored in biological sciences along with a minor in International Studies, and graduated with the class of 2023. Jianhong is continuing with research in the Fleischman lab during her gap year as she prepares for the MCAT. http://www.mpnlab.org/undergraduates daily 0.75 2025-03-25 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/fda8b5c1-5a2f-4022-85e1-94ca8a677b72/IMG_7382.JPG Undergraduates KRISTA TSAI Krista is a third-year Biological Science major and Medical humanities minor hoping to become a PA-C in her near future. She joined the lab Winter 2023 in hopes to enhance findings and research involving oncology. She became super passionate about the field of oncology when she started volunteering at St.Jude’s Infusion Center and formed deep connections with several patients and nurses. She is excited to work with the lab in discovering more about the intricacies of MPN that can directly be applied to healthcare to improve the lives of many. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/63e66263-f901-4fe4-ae13-c32ad11a4087/IMG_9282.JPG Undergraduates AALIYAH OKOJI Aaliyah joined the lab in the Spring of 2024 and is a second-year Biological Sciences major. Her primary interest is cancer biology and hematology. Aaliyah is eager to expand her knowledge and gain hands-on experience in the lab where she hopes to contribute to innovative research that advances our understanding of MPN. https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/25ad1f49-27dd-4c23-8afd-fda2e69e8ed5/pic+of+eshika+2.jpg Undergraduates ESHIKA ARORA Eshika is a fourth-year Biomedical Engineering major interested in joining the medical field after graduation. In dedication to her brother Eshan, she joined the lab in Summer 2023 to learn more about hematological malignancies. She is excited to work with the team and contribute to novel discoveries about MPN by expanding her knowledge of JAK mutations in hematopoietic stem cells, biological research, and hematology oncology. http://www.mpnlab.org/jeanette-sullivan-copy daily 0.75 2025-10-20 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/f2f618bf-8406-4624-a572-4c26c30654e4/10.17.25+STEMM+Research+Poster+Symposium+0077.JPG Lucas Wadley Lucas Wadley giving a talk as a guest speaker at Nevada State University. 10.17.2025 http://www.mpnlab.org/kaleiguillermo-ms daily 0.75 2025-09-11 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/19e10b2f-5908-45d1-806d-752fe61e30c3/08294.png Kalei Guillermo, MS http://www.mpnlab.org/camille-brzechffa daily 0.75 2025-09-11 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/61a81261-2e73-431f-8fbd-0e1442e1111e/CB-photo.jpg Camille Brzechffa http://www.mpnlab.org/contact-us-copy daily 0.75 2025-11-08 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399048729358-NFTA6H9U37I33I0G3T2N/sprague+hall.jpg Contact Us Sprague Hall http://www.mpnlab.org/join-the-lab-copy daily 0.75 2025-11-08 https://images.squarespace-cdn.com/content/v1/535b0bc3e4b05d1feab46292/1399333171209-PVOMYI5NVOKMU08J1DA0/lab+bench1.jpg Join the Lab